Why was the nitration mixture added slowly to the acetanilide solution

Why was the nitration mixture added slowly to the acetanilide solution. Add dry acetanilide (25 g) to glacial acetic acid (25 ml) in a beaker and then introduce concentrated sulphuric acid (50 ml) slowly with constant stirring to obtain clear solution. Having nitrogen present in a ring is very useful because it can be used as a directing group as well as a masked amino group. Keep the temperature in the 20-25 °C range as you add the nitrating mixture. Nitration of heterocyclic compounds - derivatives of pyrrole and thiophene Further Applications of Nitration and Sulfonation. Jan 30, 2023 · Recrystallization, also known as fractional crystallization, is a procedure for purifying an impure compound in a solvent. Feb 21, 2024 · When both solutions are cold, slowly add the HNO 3 /H 2 SO 4 solution, 1 mL per minute using a pipet, to the acetanilide solution. 3. 02 g/ml) in a large tared test tube and determine the weight to the nearest mg. Cool the hot reaction mixture in an ice/salt bath until the temperature drops to about 0. If sulfuric acid (H2SO4) is added to this solution, will a color change be observed? and add 1. This interaction Gently warm the mixture to dissolve acetanilide completely. When we perform nitration of acetanilide we maintain a slow and continuous supply of the acid mixture ( conc. (The solution will become very viscous. 4 mmol) and sodium bromide (1. Once addition is complete, bring the reaction Fix the reflux condenser with the round bottom flask. A solution of the Step 4 product (22. Nitration of compound (17) occurred in a mixture of fuming nitric and sulfuric acids below 0 °C to afford the corresponding 2-nitro derivative (40) in 33% yield. After the ice has melted, slowly 5 mL of saturated sodium Experiment 1 Procedures. Feb 4, 2020 · The reaction starts with a nitration reaction of acetanilide to form p-nitro acetanilide, followed by a reduction of the final product to produce p-amino acetanilide, creating a diazonium salt The solution will become viscous. While cooling, the solution produced large white crystals for methyl Step 1. Transfer all of the crude p-nitroacetanilide that was prepared above in Step 2 to a 100 mL round bottom flask. About 2g of powdered acetanilide and 2mL of Glacial acetic acid were mixed well in a 100mL beaker. 5 mL) to the cooled sulfuric acid solution of acetanilide. Remove the reaction from the ice bath and stir for an additional 10 minutes. 15 to 0. Definition. stir, the mixture using stirring addition of nitrating mixture. 2. You may need to warm the mixture gently to aid in this dissolution (holding the flask in your hands or immersing in a warm - not hot- water should suffice). Why is it important to add the nitric acid-sulfuric acid mixture slowly over a 15 minute period? Here’s the best way to solve it. sulphuric acid as nitrating reagent. 8. Crystallization must be conducted in order to obtain pure crystals. The solution becomes white as acetanilide precipitates. 2 g of methyl benzoate, a. The nitronium ion is a very good electrophile and is open to attack by benzene. Swirl the flask to mix the reagents thoroughly. The nitro group acts as a ring deactivator. Keep the reaction flask in an ice bath so that the temperature of the reaction mixture is maintained between 10-20 degrees. Using a medicine dropper, place 0. Chemistry questions and answers. Aniline, a potential impurity, is much more soluble in room temperature water. The mixture is held at this temperature for about half an hour. Diethyl ether is added, and then aqueous sodium bicarbonate solution. Once all the acetanilide is precipitated collect and filter in buchner funnel. It was then transferred by Pasteur pipet into a beaker and stirred for five minutes. Pour the reaction mixture slowly, with stirring, into a mixture of 50 mL of water and 10 g Jan 23, 2023 · 3. Mix these acid thoroughly. Why is the nitric/sulfuric acid mixture added to methyl benzoate solution over a 5-min period? By allowing the reaction to take place slowly, we can limit the amount of free NaO2+ that is available for nitration. Stir the mixture vigorously to hydrolyse excess of acetic anhydride. 5 mL (1/2 pipette) of concentrated sulfuric acid and 0. In an aqueous solution containing sodium bicarbonate, aniline reacts quickly with bromine to give 2,4,6-tribromoaniline. He expected that the product would be a diol. Draw an energy diagram for the nitration of benzene. 1 / 23. 1). . Given that the pKa of H2SO4 is -9 and that of HNO3 is -1. See notes on previous page regarding safe handling of this acid. In another small vial (cooled in ice), carefully add 0. 1 mL of H2SO4 and stirred gently for two minutes to dissolve the acetanilide. of glacial acetic acid, stirring to ensure that all of the acetanilide has dissolved. Question: 16 EAS Reaction 2 Fuming sulfuric acid is a mixture of concentrated sulfuric acid and sulfur trioxide. When both solutions are cold add the nitrating mixture, 1 mL at a time, to the constantly stirred acetanilide solution keeping it in the ice bath 5. What color would a K2CrO4 solution be? b. The crystals were the vacuum Recrystallization of Acetanilide Expand. Most compounds are nitrated by an ionic mixture of strong acids containing nitric acid and sulfuric acid. Nitration. It lists the reagents and amounts needed, including acetanilide, glacial acetic acid, concentrated sulfuric acid, nitric acid, crushed ice and methanol. Step 1: An acid-base reaction takes place between the oxygen of the carbonyl and one of our hydrogen ions. 0 mL concentrated nitric acid (measured in 10- mL graduated cylinder) drop- wise using a small graduated plastic pipette and mix by gentle swirling. sulfurikocid usually on ice bath and then slowly add nitric acid , keeping the solution at constant temperature. nitric acid and conc. Crystallization. Once all of the nitrating mixture has been added, allow the reaction mixture to stand at room temperature for 15 minutes. Bromine. Sulfuric acid is used because nitric acid is a slow electrophile. Activated carbon added to hot solvent can cause the solution to boil over. Place the flask in an ice bath. This means that as temperature increases, the amount of solute that can be dissolved in a solvent Stir the resulting mixture well with a glass stir rod, slowly add concentrated sulphuric acid (2 ml. 5 °C. Aug 2, 2017 · The methyl benzoate nitration formed white solid, and the acetanilide nitration for a light yellow solid. Nitration of acetanilide. b/c the pi electrons are delocalized throughout the system and therefore are much less available to attack on an electrophile 8. -. Cool the nitrating mixture to room temperature. Draw the intermediates, starting materials, and products. While cooling, the solution produced large white crystals for methyl Apr 30, 2018 · All about the nitration and sulfonation electrophilic aromatic substitution reactions of benzene, their mechanisms, examples, and more. Nitration of methyl benzoate compound is an electrophilic substitution reaction. 6 days ago · Complete step by step solution: We know that when acetanilide is treated with the nitrating mixture i. 5 mL of conc. Make sure you use equations and the mechanism of formation of the nitronium ion (NO2+) to support your answer. In organic chemistry, nitration is a general class of chemical processes for the introduction of a nitro group ( −NO2) into an organic compound. Keep the reaction flask in an ice bath. Write a detailed mechanism for the sulfonation of benzene, including all resonance forms. Nitration of aniline requires very strong conditions, however, and the yields (mostly m-nitroaniline) are poor. Add the nitrating mixture DROPWISE using a medicine dropper. (b) Add mixture of concentrated nitric acid and sulphuric acid into the solution of acetanilide slowly and carefully. Heat the crude sample carefully in a small beaker containing 20 ml of water. I Placed 1. After complete addition of sulfuric acid, add approximately 2. The Jan 23, 2023 · Nitration happens when one (or more) of the hydrogen atoms on the benzene ring is replaced by a nitro group, NO 2. 5 mL of sulfuric acid in a 50 mL Erlenmeyer flask b. Here’s the best way to solve it. p-Nitroacetanilide is prepared by the nitration of acetanilide by using a mixture of conc. Swirl the mixture and set aside to be used later. In the nitration of methyl benzoate, why is it important to pour the reaction mixture over ice rather than cold water, and what is the limiting reagent in this nitration reaction using sulfuric acid, methyl benzoate, and nitric acid? There are 2 steps to solve this one. Nitration reaction can be done generally in presence of mixed acid or the mixture of concentrated nitric acid and concentrated sulfuric acid and the nitronium ion is generated as the electrophile. While cooling, the solution produced large white crystals for methyl After all the nitrating mixture has been added, allow the solution to stand at room temperature for 40 minutes in order for the reaction to go to completion. Add 1-2 drops and swirl, monitoring the temperature carefully. nitric acid and 0. 0 mmol) dissolved in 50 ml 20% triethylamine/pyridine was cooled to 0°C and saturated with H 2 S for 5 minutes. A few drops more of the better solvent are then added to put the solute back into solution, and the mixture is allowed to cool to effect crystallization. Place the beaker in a freezing mixture of ice and salt to cool the solution below 5 oC. Swirl the flask in the ice bath after each portion is added. call drop, this solution was added to the acetanilide solution during the conical flask. The strongly nitrating mixture itself forces the reaction to be slower O meta Mechanism: A detailed mechanism illustrating nitration reactions involving nitric acid (HNO3) and sulfuric acid (H2SO4). After completion of the addition, white crystals are formed after stirring the reaction mixture for 10 minutes in the heat. Weigh out 2. 11. Continue adding the nitrating mixture in 5 drop increments to the reaction flask, with inter mittent swirling. It is important that the acid is added slowly and hipersed into the reaction mature by stirring with a glass rod, te prevent a teperature, which could result in a dark coloured solution and a very low yield of product. The term also is applied incorrectly to the different process of forming nitrate esters ( −ONO2) between alcohols and nitric acid (as occurs in the synthesis of nitroglycerin ). After the reaction is completed, allow the reaction flask to stir at room temperature for 30 minutes. Theory Aniline is an aromatic primary amine. stir, the mixture using stirring When both solutions are cold, slowly add the nitric acid-sulfuric acid solution, I drop at a time, to the acetanilide solution. - After the boiling, during the cooling process, the mixture turned a clear, dark brown, which after a few minutes changed to a red colour. Without sulfuric acid the reaction would not occur. Finish by adding a few more mL of hot water and by gravity filtering the hot solution. Cool the solution in an ice bath and Continue to cool the mixture in the ice bath to reduce the heat, which produced in the reaction. The method of purification is based on the principle that the solubility of most solids increases with increased temperature. Stir the mixture and add concentrated sulfuric acid (3 mL). sulfuric acid in a test tube, and chill the test tube in an ice bath. Note: If the sample does not readily dissolve, you may also try stirring the solution with a glass stirring rod. 4mL of con. The pH value is used to determine whether the solution acidic of the base. 4 Aim To prepare phenyl–azo–β-naphthol (an azo dye). 5 mL (1/2 pipette) of concentrated nitric acid. EXPERIMENT 10. 4 mL of methyl benzoate to the sulfuric acid. If the mixture is colored, a small amount of activated carbon can be added. 100% (11 ratings) If the addition is too f …. Answer. When both solutions are cold, slowly add the HNO3/H2SO4 solution, 1 mL at a time, to the acetanilide solution. Term. Dissolve using 5 ml. Put 1. Use a Pasteur pipet to slowly add the nitrating solution in the test tube to the Erlenmeyerflask containing the acetanilide and sulphuric acid. 5 mL of concentrated sulfuric acid. Use an eyedropper or Pasteur pipette to slowly add the nitrating solution in the test tube to the Erlenmeyer flask containing the acetanilide and sulfuric acid; the flask should remain in the ice bath during this entire process. 5 g of acetanilide. Step 3: Preparation of p-Nitroaniline. c. A chilled HNO3/H2SO4 solution was added to the acetanilide solution 1mL at a time. B. Add the acetanilide from the mini-test tube to the first solvent. Also along with this, as a minor product, o- nitroacetanilide is also formed. When both solutions are cold, slowly add the HNO 3 /H 2 SO 4 solution, 1 mL per minute using a pipet, to the acetanilide solution. reaction used to introduce a nitro group into an aromatic compound. Pour the hot mixture in a beaker containing ice cold water with constant stirring. If you spill any acid on your hands wash them immediately. In a small beaker add 1. Prepare the acetanilide a. Add 10 ml of. Benzene is treated with a mixture of concentrated nitric acid and concentrated sulfuric acid at a temperature not exceeding 50°C. Add 5 drops of the nitrating mixture to the reaction flask, and then swirl to mix the solution. Procedure: To a 125 mL Erlenmeyer flask containing a mixture of 95% ethanol (6 mL) and acetic acid (5 mL), dissolve acetanilide (7. After all the nitrating mixture has been added, allow the solution to stand at room temperature for 40 minutes in order for the reaction to go to completion. To RECRYSTALLIZE the acetanilide, mix the sample with approximately 15 mL of hot water per gram of sample and gradually add several mL of water at a time until the solution is complete. The nitroacetanilides are not isolated in this reaction scheme. · While making the nitrating mixture cool the conc. This solution has been added to the add-on. Nitration is the process of adding a nitro group into an organic compound like aromatic compound, alcohol, glycol, glycerine, aromatic amine, and paraffin. ) and then chill the warm solution in a bath of crushed ice and salt. Acetanilide is toxic and an irritant. When both solutions are cold, slowly add the nitric acid-sulfuric acid solution, I drop at a time, to the acetanilide solution. Add 1 go of acetanilide to the acid c. Unlock. Since o- nitroacetanilide is much soluble in water, it is easy to isolate p –nitro Using a syringe, add 0. Mar 1, 2015 · acetanilide is nitrated by mixture of ≈100% nitric and sulfuric acids, even at 0 0 C, you can get 2,4-dinitroacetanilide. Cool the solution and add concentrated sulphuric acid slowly with constant stirring. Why is it important that the nitration of benzene by nitric acid occurs in sulfuric acid? 4. 5 mL of concentrated nitric acid to 4. The crystals were the vacuum filtered with a Buchner funnel. 5. Why are aromatic compounds resistant to simple electrophilic addition reactions? Click the card to flip 👆. This was added slowly to ensure the mixture stayed between 10 and 20 degrees Celsius. The crude product was recrystallized by adding a distilled water and ethanol slowly while heating the product. Step 2: A molecule of water acts as a nucleophile (electron donor) to attack the carbon. common electrophile used for nitration (and how is it formed) nitronium ion (NO2+) - formed in the flask by treating HNO3 with H2SO4 because it is unstable. It was illustrated by the results of this lab that our goals were met and this experiment was successful, not only by the product made but by the melting point which allowed us to infer that our product was m-nitroaniline over the other two isomers NOW using a glass droppie pipette add the nitric acid over a period of approximately 10 minutes. 4, explain why nitration occurs more rapidly in a mixture of concentrated nitric and sulfuric acids than in concentrated nitric acid alone. ) Chill 10 mL of a mixture of HNO3/H2SO4 (this has been prepared for you and is in a bottle in the hood) in a 50-ml Erlenmeyer flask in an ice bath. Add 25 g (0. View the full answer. While cooling, the solution produced large white crystals for methyl The aromatic nitration of acetanilide is an exothermic reaction; Answered step-by-step. Add 10 mL of water and 10 mL of concentrated hydrochloric acid. Heat the mixture gently for about 15-20 minutes in oil bath. Swirl the solution while on ice to mix well 2. Repeat steps 3 and 4 for the remaining solvents. Add 5 ml of distilled water to the test tube and then add 20 drops of acetic anhydride again using a medicine dropper (Fig. 8 g). Chill the acetanilide/acetic acid/sulphuric acid mixture to about 0 °C in the ice-salt bath and slowly add (dropwise - Pasteur pipette) the nitric acid/sulphuric acid mixture to the acetanilide solution. Place a magnetic stir bar in a 25 mL Erlenmeyer flask and add 0. What happens to the mixture? a. The acetanilide does not fully dissolve but gives a "slurry in the acids b) The solubility of the wet, crude acetanilide at 80 is 700 mg per 10 ml (this is assuming This document provides the procedure and discussion for nitrating acetanilide. Place a rubber stopper in the end of the solvent test tube and shake to dissolve the solid. If the nitration of acetanilide reaction mixture is allowed to become too hot, it may lead to the fo During the nitration of acetanilide (Step 4 of the procedure), care is taken to keep the reaction mixture cool. It can be used to sulfonate a benzene ring. Mix 0. Indicate the major product (s) formed on nitration of each of the fol- lowing compounds: benzene, toluene, chlorobenzene, and benzoic acid. Explain why nitration of aniline is so sluggish and why it gives mostly metasubstitution. - electron-rich aromatic ring reacts with electrophiles. 1. Continue to cool the reaction mixture. Repeating the reaction in a weaker nitrating system with acetic anhydride and nitric acid resulted in recovery of starting material. added 3. b. H2SO4 ) to the acetanilide in glacial acetic acid solution …. Acetanilide is moderately soluble in boiling water, but it's much less soluble in room temperature and cold water. 6. rawer! ate: Experiment 6: EAS Homework Assignment 2. concentrated sulphuric acid so that a clear solution is obtained. The reaction is similar to the nitration reaction with sulfuric acid and nitric acid. H2SO4 was added to the mixture. HNO 3 + conc. It was then 6 days ago · Water is then added to dissolve the barrier and ceric nitrate. Acetanilide Overview. The flask should not become perceptibly warm to the touch; the addition requires 10 to 15 minutes. NOTE: Rapid addition of the nitratingsolution will cause the reaction mixture to heat up, turning the mixture dark brodark brown product is difficult to recrystallize and will affect the melting 7. a mixture of sulphuric and nitric acid, it forms p- nitroacetanilide. After the addition is completed, allow reaction to proceed at room temperature for 30 mins and monitor temp to make sure it isn’t above 30 o C. Allow the filtrate to cool slowly. Nitration Reaction: It is an electrophilic substitution reaction that helps to incorporate nitro groups into a molecule. 1 Why is it important to add the acid mixture to the acetanilide slowly? 4. Separate the reaction mixture once all of the acetanilide has formed. Keep the reaction flask in an ice bath so that the temperature explain why nitration of aniline is slow and give mostly meta product but nitration of acetanilide is quick and give mostly para products?? This problem has been solved! You'll get a detailed solution from a subject matter expert that helps you learn core concepts. Using the small plastic dropping bottles, add 20 drops of concentrated acetic acid, 40 drops of concentrated sulfuric acid, and 16 drops of concentrated nitric acid. Add approximately 5 mL of concentrated sulfuric acid to the flask, agitate to dissolve the acetanilide and cool the mixture in an ice bath. Chill the solution to about 10 °C in an ice bath. Q. The vessel was then sealed and the mixture stirred 90 minutes at ambient temperature. 5- p-nitroacetanilide Molecular formula - May 2, 2024 · The mixture is added dropwise, stirring gently and regulating the addition so that the temperature of the reaction mixture does not exceed 35 °C. 4. Acetone and ethanol are flammable irritants; wash thoroughly if skin contact is made. In this reaction View the full answer Step 2. Conclusion: The purpose of this experiment was to perform the nitration of acetanilide and from the melting point, determine which isomer it was. Stir after each drop. MCC O Chem: Lab 19 Competitive Nitration of Acetanilide and Methyl Benzoate. Interpret the infrared spectrum of methyl m-nitrobenzoate. In acetanilide, the starting material, this electron donation from the lone pair of nitrogen decreases the stability of the attached benzene ring. If the pH value of the solution, fewer than seven, the solution is known as the acidic solution, or if the solution has more H ions than the OH ions, than the solution is recognized as an acidic solution. So that the acetanilide is 'in solution' when the nitrating mixture is added. d. 20 g of aniline (about 10 drops) (d = 1. Aug 16, 2021 · Measure out 0. The solution becomes warm, keep the mixture in ice-bath and clear solution is obtained. Procedure. The solution was cooled and cooled sulfuric acid was added, then the mixture was cooled again. Nitration is used to add nitrogen to a benzene ring, which can be used further in substitution reactions. After 10 minutes, add a few pieces of crushed ice directly to the reaction mixture. To prevent the acetanilide from reacting to quickly when the nitrating mixture is added. In this part of the lab, you'll purify acetanilide by recrystallization from an aqueous solution. Cool the acetanilide solution in an ice bath and then add slowly, with swirling, 3 mL of concentrated sulfuric acid. Step B: nitration of acetanilide (II) to give p-nitroacetanilide (III). Sulfuric acid protonates nitric acid to form the nitronium ion (water molecule is lost). Pour the reaction mixture slowly, with stirring, into a mixture of 50 mL of water and 10 g The methyl benzoate nitration formed white solid, and the acetanilide nitration for a light yellow solid. Slowly add the sulfuric acid to the nitric acid f. In acid, however, it exists as the director. Indicate the major product (s 1. Label the transition states. 6 mL), making sure that the temperature does not rise above 20 °C. 185 mol) of finely powdered, dry acetanilide to 25 ml of glacial acetic acid contained in a 500-ml beaker introduce into the well-stirred mixture 92 g (50 ml) of concentrated sulphuric acid. Stir the reaction mixture carefully during addition. The nitric acid and sulfuric acid mixture must be added dropwise to the acetanilide solution to keep the temperature below 10 degrees Celsius and prevent over Preparation of 5,7-dimethyl-1H-indazole-3-carboximidothioic acid. To prevent dinitration of the acetanilide, the nitrating mixture of concentrated nitric acid and sulfuric acids is added in small portions to the acetanilide solution (and not vice versa), so that the concentration of the nitrating agent is kept at a minimum. What do you think might be the consequences of allowing the reaction mixture to become too wam? Nov 21, 2023 · The bromination of acetanilide balanced chemical equation is C 6 H 5 N H C O C H 3 + B r 2 → B r C 6 H 4 N H C O C H 3 + H B r. Nitrating mixture is highly corrosive and is a fire hazard. Expert-verified. Also, when crystallised from ethyl alcohol, the p-nitro acetanilide crystallises mostly as colourless crystals, whereas, the ortho isomer remains in the same solution. Add this acidic mixture dropwise to the large reaction tube. 9. That means that you would use a lower temperature to prevent more than one nitro group being substituted - in this case, 30°C rather than 50°C. The compounds involved are: Acetanilide. Solved by verified expert 1. The mixture of the two acids releases nitronium ion(+ 2 Carefully place a magnetic stirring bar in the flask containing acetanilide and place it, in the ice bath, on the stir plate; turn the stirring on. e. Next, this was warmed on a steam bath until the acetanilide dissolved. So that the acetanilide is 'in solution' when the sulfuric acid is added. Surround the beaker with a freezing mixture of ice and salt The nitration of methylbenzene (toluene) Methylbenzene reacts rather faster than benzene - in nitration, the reaction is about 25 times faster. Experimental Procedures. DO NOT LEAVE IT FOR MORE THAN ONE HOUR or decomposition or a second nitration may start to occur. May 30, 2023 · Step 1: Preparation of p-Nitroacetanilide from Acetanilide. Thus, the p-nitro acetanilide can be formed as a major product. In the experiment Nitration of Methyl Benzoate why is it important to add the nitric acid-sulfuric acid mixture slowly over a 15 minute period? A student added added an equivalent of 3,4-epoxy-4-methylcyclohexanol to an ether solution of methyl magnesium bromide and then added dilute hydrochloric acid. The mixture becomes warm and a clear solution results. Place the Erlenmeyer flask in an ice bath and add the solution of the nitrating agent drop wise over 5 minutes. A catalyst (such a. To stabilize the acetanilide prior to the addition of sulfuric acid. Acetamido group, being a bulky group, will cause the steric hindrance at the position of ortho. Add the acetic anhydride to the solution of aniline hydrochloride in water, mix by swirling, and immediately add the sodium acetate solution. the better solvent at its boiling point, and to add the weaker solvent dropwise until a faint cloudiness persists, indicating that the solute is starting to come out of solution. NOTE: Rapid addition of the nitrating solution will cause the reaction mixture to heat up, turning the mixture dark A mixture composed of 3-chlorobenzoic acid and acetanilide is added to a separatory funnel. - In step 15, we slowly added and dissolved the remaining crude product in boiling ethanol, which made the solution turn opaque orange. Place the reaction flask in an ice bath (at least 5oC) for 5 minutes (keep this reaction in the hood). The methyl benzoate nitration formed white solid, and the acetanilide nitration for a light yellow solid. Using the pipet and bulb, add the mixed acid in small portions (about 0. Add two boiling chips and reflux the mixture at a gentle boil for 15-20 minutes using your heating mantle. Sulfuric acid is needed in order for a good electrophile to form. During this operation, be sure to keep the chilled mixture well stirred and do not allow the temperature of the mixture to rise above 10 °C. I cooled the acetanilide solution in an ice bath by placing the ice bath container on the stir plate under the flask. Previous question Next question. Apart from that, the reaction is just the same - using a. aromatic nitration. In a 100 mL conical flask place 5 g of your prepared acetanilide from Lab # 4. Part C Explain why nitration of aniline is so sluggish and why it gives mostly meta substitution: The NH2 group is a strongly activating ammonium ion-a strongly deactivating -director. Nitrous acid Allow both to chill until cold e. It forms diazonium salt when treated with nitrous acid at 0-5 °C. It is unstable and should be generated in situ. Yellow oily nitrobenzene is formed. Add the nitric acid slowly using your medicine dropper. With stirring, slowly add fuming nitric acid (0. Heat the mixture on a hot plate to dissolve all of the solid (it will look like honey) d. 10. Nitration of Methyl Benzoate 4. 06 g of acetanilide into a clean 25 mL round bottom flask. 1 point Choose the product (s) of the sulfonation of acetanilide: H2SO/SO, i HOS ao arot 1 and 2 2 and Acid. Mar 17, 2019 · After the acid mixture was added, the reaction mixture was removed from the ice to warm to room temperature, with stirring. After addition, the beaker is removed from the ice bath and allowed to stand at room temperature for 5 min. 7 grams of acetanilide and add it to a 125 mL Erlenmeyer flask. Why is it important to add the nitric acid-sulfuric acid mixture slowly? 4. 6 mL of acetic anhydride and prepare a solution of 530 mg of sodium acetate in 3 mL of water. SO 3 and H 2 SO 4 (fuming) 2. ow jx jn ts tx le wh bu aw ao